Predictors of Axillary Lymph Node Metastases (ALNM) in a Korean Population with T1-2 Breast Carcinoma: Triple Negative Breast Cancer has a High Incidence of ALNM Irrespective of the Tumor Size
Identifieur interne : 005695 ( Main/Exploration ); précédent : 005694; suivant : 005696Predictors of Axillary Lymph Node Metastases (ALNM) in a Korean Population with T1-2 Breast Carcinoma: Triple Negative Breast Cancer has a High Incidence of ALNM Irrespective of the Tumor Size
Auteurs : Jong Hoon Lee [Corée du Sud] ; Sung Hwan Kim [Corée du Sud] ; Young Jin Suh [Corée du Sud] ; Byoung Yong Shim [Corée du Sud] ; Hoon Kyo Kim [Corée du Sud]Source :
- Cancer Research and Treatment : Official Journal of Korean Cancer Association [ 1598-2998 ] ; 2010.
Abstract
We estimated the likelihood of breast cancer patients having axillary lymph node metastases (ALNM) based on a variety of clinical and pathologic factors.
Three hundred sixty-one breast cancer patients without distant metastases and who underwent breast conserving surgery and axillary lymph node dissection (ALND) (level I and II) or modified radical mastectomy (MRM) were identified, and we retrospectively reviewed their pathology records and treatment charts.
Positive axillary lymph nodes were detected in 104 patients for an overall incidence of 28.8%: 2 patients (5%) with T1a tumor, 5 (9.2%) with T1b tumor, 24 (21.8%) with T1c tumor and 73 (44.2%) with T2 tumor. On the multivariate analysis, an increased tumor size (adjusted OR=11.87, p=0.02), the presence of lymphovascular invasion (adjusted OR=7.41, p<0.01), a triple negative profile (ER/PR-, Her2-) (adjusted OR=2.09, p=0.04) and a palpable mass at the time of diagnosis (adjusted OR=2.31, p=0.03) were all significant independent factors for positive ALNM.
In our study, the tumor size, the presence of lymphovascular invasion, a triple negative profile and a palpable mass were the independent predictive factors for ALNM. The tumor size was the strongest predictor of ALNM. Thus, the exact estimation of the extent of tumor is necessary for clinicians to optimize the patients' care. Patients with a triple negative profile have a high incidence of ALNM irrespective of the tumor size.
Url:
DOI: 10.4143/crt.2010.42.1.30
PubMed: 20369049
PubMed Central: 2848750
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002D41
- to stream Pmc, to step Curation: 002D40
- to stream Pmc, to step Checkpoint: 003275
- to stream Ncbi, to step Merge: 003A40
- to stream Ncbi, to step Curation: 003A40
- to stream Ncbi, to step Checkpoint: 003A40
- to stream Main, to step Merge: 005744
- to stream Main, to step Curation: 005695
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Predictors of Axillary Lymph Node Metastases (ALNM) in a Korean Population with T1-2 Breast Carcinoma: Triple Negative Breast Cancer has a High Incidence of ALNM Irrespective of the Tumor Size</title><author><name sortKey="Lee, Jong Hoon" sort="Lee, Jong Hoon" uniqKey="Lee J" first="Jong Hoon" last="Lee">Jong Hoon Lee</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Radiation Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Sung Hwan" sort="Kim, Sung Hwan" uniqKey="Kim S" first="Sung Hwan" last="Kim">Sung Hwan Kim</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Radiation Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Suh, Young Jin" sort="Suh, Young Jin" uniqKey="Suh Y" first="Young Jin" last="Suh">Young Jin Suh</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Surgical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Surgical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Shim, Byoung Yong" sort="Shim, Byoung Yong" uniqKey="Shim B" first="Byoung Yong" last="Shim">Byoung Yong Shim</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Medical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Medical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Hoon Kyo" sort="Kim, Hoon Kyo" uniqKey="Kim H" first="Hoon Kyo" last="Kim">Hoon Kyo Kim</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Medical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Medical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20369049</idno><idno type="pmc">2848750</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848750</idno><idno type="RBID">PMC:2848750</idno><idno type="doi">10.4143/crt.2010.42.1.30</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">002D41</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002D41</idno><idno type="wicri:Area/Pmc/Curation">002D40</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002D40</idno><idno type="wicri:Area/Pmc/Checkpoint">003275</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003275</idno><idno type="wicri:Area/Ncbi/Merge">003A40</idno><idno type="wicri:Area/Ncbi/Curation">003A40</idno><idno type="wicri:Area/Ncbi/Checkpoint">003A40</idno><idno type="wicri:doubleKey">1598-2998:2010:Lee J:predictors:of:axillary</idno><idno type="wicri:Area/Main/Merge">005744</idno><idno type="wicri:Area/Main/Curation">005695</idno><idno type="wicri:Area/Main/Exploration">005695</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Predictors of Axillary Lymph Node Metastases (ALNM) in a Korean Population with T1-2 Breast Carcinoma: Triple Negative Breast Cancer has a High Incidence of ALNM Irrespective of the Tumor Size</title><author><name sortKey="Lee, Jong Hoon" sort="Lee, Jong Hoon" uniqKey="Lee J" first="Jong Hoon" last="Lee">Jong Hoon Lee</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Radiation Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Sung Hwan" sort="Kim, Sung Hwan" uniqKey="Kim S" first="Sung Hwan" last="Kim">Sung Hwan Kim</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Radiation Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Suh, Young Jin" sort="Suh, Young Jin" uniqKey="Suh Y" first="Young Jin" last="Suh">Young Jin Suh</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Surgical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Surgical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Shim, Byoung Yong" sort="Shim, Byoung Yong" uniqKey="Shim B" first="Byoung Yong" last="Shim">Byoung Yong Shim</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Medical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Medical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Hoon Kyo" sort="Kim, Hoon Kyo" uniqKey="Kim H" first="Hoon Kyo" last="Kim">Hoon Kyo Kim</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Medical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Medical Oncology, St. Vincent's Hospital, The Catholic University College of Medicine, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cancer Research and Treatment : Official Journal of Korean Cancer Association</title><idno type="ISSN">1598-2998</idno><idno type="eISSN">2005-9256</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>We estimated the likelihood of breast cancer patients having axillary lymph node metastases (ALNM) based on a variety of clinical and pathologic factors.</p></sec><sec><title>Materials and Methods</title><p>Three hundred sixty-one breast cancer patients without distant metastases and who underwent breast conserving surgery and axillary lymph node dissection (ALND) (level I and II) or modified radical mastectomy (MRM) were identified, and we retrospectively reviewed their pathology records and treatment charts.</p></sec><sec><title>Results</title><p>Positive axillary lymph nodes were detected in 104 patients for an overall incidence of 28.8%: 2 patients (5%) with T1a tumor, 5 (9.2%) with T1b tumor, 24 (21.8%) with T1c tumor and 73 (44.2%) with T2 tumor. On the multivariate analysis, an increased tumor size (adjusted OR=11.87, p=0.02), the presence of lymphovascular invasion (adjusted OR=7.41, p<0.01), a triple negative profile (ER/PR-, Her2-) (adjusted OR=2.09, p=0.04) and a palpable mass at the time of diagnosis (adjusted OR=2.31, p=0.03) were all significant independent factors for positive ALNM.</p></sec><sec><title>Conclusion</title><p>In our study, the tumor size, the presence of lymphovascular invasion, a triple negative profile and a palpable mass were the independent predictive factors for ALNM. The tumor size was the strongest predictor of ALNM. Thus, the exact estimation of the extent of tumor is necessary for clinicians to optimize the patients' care. Patients with a triple negative profile have a high incidence of ALNM irrespective of the tumor size.</p></sec></div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Lee, Jong Hoon" sort="Lee, Jong Hoon" uniqKey="Lee J" first="Jong Hoon" last="Lee">Jong Hoon Lee</name></noRegion><name sortKey="Kim, Hoon Kyo" sort="Kim, Hoon Kyo" uniqKey="Kim H" first="Hoon Kyo" last="Kim">Hoon Kyo Kim</name><name sortKey="Kim, Sung Hwan" sort="Kim, Sung Hwan" uniqKey="Kim S" first="Sung Hwan" last="Kim">Sung Hwan Kim</name><name sortKey="Shim, Byoung Yong" sort="Shim, Byoung Yong" uniqKey="Shim B" first="Byoung Yong" last="Shim">Byoung Yong Shim</name><name sortKey="Suh, Young Jin" sort="Suh, Young Jin" uniqKey="Suh Y" first="Young Jin" last="Suh">Young Jin Suh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005695 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005695 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:2848750
|texte= Predictors of Axillary Lymph Node Metastases (ALNM) in a Korean Population with T1-2 Breast Carcinoma: Triple Negative Breast Cancer has a High Incidence of ALNM Irrespective of the Tumor Size
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:20369049" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |